JPH0134231B2 - - Google Patents

Info

Publication number
JPH0134231B2
JPH0134231B2 JP56113578A JP11357881A JPH0134231B2 JP H0134231 B2 JPH0134231 B2 JP H0134231B2 JP 56113578 A JP56113578 A JP 56113578A JP 11357881 A JP11357881 A JP 11357881A JP H0134231 B2 JPH0134231 B2 JP H0134231B2
Authority
JP
Japan
Prior art keywords
group
kanamycin
water
amino
epicanamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP56113578A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5815994A (ja
Inventor
Hamao Umezawa
Sumio Umezawa
Ryoji Ishido
Shunzo Fukatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP56113578A priority Critical patent/JPS5815994A/ja
Priority to US06/398,838 priority patent/US4455419A/en
Priority to FR8213032A priority patent/FR2510574B1/fr
Priority to DE3227178A priority patent/DE3227178C2/de
Priority to GB08221237A priority patent/GB2104514B/en
Priority to IT1982A09478A priority patent/IT8209478A1/it
Priority to IT09478/82A priority patent/IT1192483B/it
Publication of JPS5815994A publication Critical patent/JPS5815994A/ja
Publication of JPH0134231B2 publication Critical patent/JPH0134231B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP56113578A 1981-07-22 1981-07-22 ２′位修飾カナマイシン誘導体およびその製造法 Granted JPS5815994A (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP56113578A JPS5815994A (ja) 1981-07-22 1981-07-22 ２′位修飾カナマイシン誘導体およびその製造法
US06/398,838 US4455419A (en) 1981-07-22 1982-07-16 2'-Modified kanamycins and production thereof
FR8213032A FR2510574B1 (fr) 1981-07-22 1982-07-21 Kanamycines modifiees en 2', leur procede d'obtention et leur utilisation comme agents antibacteriens
DE3227178A DE3227178C2 (de) 1981-07-22 1982-07-21 2'-Modifizierte Kanamycine, Verfahren zu deren Herstellung und diese Verbindungen enthaltende antibakterielle Mittel
GB08221237A GB2104514B (en) 1981-07-22 1982-07-22 2'-modified kanamycins and production thereof
IT1982A09478A IT8209478A1 (it) 1981-07-22 1982-07-22 Kanamicine 2'-modificate e produzione di queste
IT09478/82A IT1192483B (it) 1981-07-22 1982-07-22 Kanamicine 2'-modificate e produzione di queste

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56113578A JPS5815994A (ja) 1981-07-22 1981-07-22 ２′位修飾カナマイシン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
JPS5815994A JPS5815994A (ja) 1983-01-29
JPH0134231B2 true JPH0134231B2 (en]) 1989-07-18

Family

ID=14615779

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56113578A Granted JPS5815994A (ja) 1981-07-22 1981-07-22 ２′位修飾カナマイシン誘導体およびその製造法

Country Status (6)

Country Link
US (1) US4455419A (en])
JP (1) JPS5815994A (en])
DE (1) DE3227178C2 (en])
FR (1) FR2510574B1 (en])
GB (1) GB2104514B (en])
IT (2) IT1192483B (en])

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
GB0411948D0 (en) * 2004-05-28 2004-06-30 Univ Leeds Compounds
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
CA2654561A1 (en) * 2006-06-02 2007-12-13 Meiji Seika Kaisha, Ltd. Novel aminoglycoside antibiotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868360A (en) * 1972-10-24 1975-02-25 Schering Corp Process for preparing 2-deroxy-3-desamino-2,3-epimino-aminoglycosides and intermediates useful therein
JPS5850235B2 (ja) * 1974-12-11 1983-11-09 明治製菓株式会社 ３′，４′−α−エポキシ−リボスタマイシン又は−カナマイシンＢの製造法
US4171356A (en) * 1976-10-28 1979-10-16 Schering Corporation 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor
JPS5663993A (en) * 1979-10-30 1981-05-30 Microbial Chem Res Found Novel preparation of tobramycin

Also Published As

Publication number Publication date
FR2510574B1 (fr) 1985-06-28
DE3227178C2 (de) 1984-06-20
DE3227178A1 (de) 1983-02-24
JPS5815994A (ja) 1983-01-29
IT8209478A0 (it) 1982-07-22
IT1192483B (it) 1988-04-13
FR2510574A1 (fr) 1983-02-04
IT8209478A1 (it) 1984-01-22
US4455419A (en) 1984-06-19
GB2104514B (en) 1985-04-11
GB2104514A (en) 1983-03-09

Similar Documents

Publication Publication Date Title
US4117221A (en) Aminoacyl derivatives of aminoglycoside antibiotics
GB2036020A (en) Production of a selectively protected n-acylated derivatives of an aminoglycosidic antibiotic
US4170642A (en) Derivatives of kanamycin A
US3925354A (en) Process for the production of an 1-n-(s)-alpha- substituted-w-aminoacyl) derivative of neamine, 3', 4'-dideoxyneamine, ribostamycin or 3',4'-dideoxyribostamycin
EP0601909B1 (en) Dibekacin derivatives and arbekacin derivatives active against resistant bacteria, and the production thereof
JPH0134231B2 (en])
GB1564164A (en) Production of kanamycin c and its deoxy derivatives
GB2068366A (en) A paromomycin derivative
US4008362A (en) 1-N-((S)-α-substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof
US4547492A (en) 1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same
JPH0764866B2 (ja) １−ｎ−（４−アミノ−３−フルオロ−２−ヒドロキシブチリル）カナマイシン類
HK51584A (en) Process for the preparation of 1-n-acyl-aminoglycosides
US4008218A (en) 1-N-((S)-α-substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof
JPS636556B2 (en])
US4298727A (en) 3',4'-Dideoxykanamycin A and 1-N-(S)-α-hydroxy-ω-aminoalkanoyl) derivatives thereof
EP0040764A1 (en) Novel aminoglycosides, and antibiotic use thereof
US4357466A (en) Processes for the production of 3'-deoxykanamycin A and intermediates
JPH0130837B2 (en])
JPS6146469B2 (en])
EP0185323B1 (en) 2',3'-dideoxy-2'-fluorokanamycin a and 1-n-(alpha-hydroxy-omega-aminoalkanoyl) derivatives thereof
JP3215732B2 (ja) 耐性菌に有効なジベカシン誘導体またはアルベカシン誘導体とそれらの製造法
JPS6312079B2 (en])
JPS5984899A (ja) ３−デメトキシイスタマイシンｂ誘導体
KR910003429B1 (ko) 아미노글리코사이드계 항생물질 유도체의 제조방법
JPH0631296B2 (ja) ２′，３′−ジデオキシ−２′−フルオロカナマイシンａ誘導体、およびその製造法